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Known as 'the Andalucia of Bolivia', Tarija is a tranquil little city near the Argentinian border that is well-known for its fruit and wine industry.
The city has some exquisite colonial buildings, an archaeology museum with displays of local prehistoric critters (a giant sloth and a saber-tooth tiger being two of the offerings) and wine buffs can sample the best Bolivia has to offer at a some excellent nearby vineyards.
Or cool off with the locals in the gigantic reservoir that lies a few kilometres outside Tarija. You can also rent canoes and cabins here.